UPPSALA KIDNEY OXYGEN MEETING

August 17-20, 2017
Uppsala, Sweden

SCIENTIFIC DESCRIPTION

Recent advances have solidified deranged renal oxygen homeostasis, i.e. intrarenal tissue hypoxia, as a key event for both the onset and the progression of chronic kidney disease (Mimura and Nangaku 2010). In 1998, Fine and colleagues proposed that reduced renal blood flow in the peritubular capillaries results in decreased kidney tissue oxygenation which, when reaching a threshold, promotes tubulointerstitial fibrosis via several different parallel pathways ultimately leading to chronic kidney disease (Fine, Orphanides et al. 1998). This theory has gained increasing support over the last recent years. Specifically, experimental data have highlighted renal hypoxia as a crucial factor for kidney disease in diabetes (Rosenberger, Khamaisi et al. 2008), hypertension (Welch, Baumgartl et al. 2001), polycystic kidney disease (Bernhardt, Wiesener et al. 2007) and chronic glomerulonephritis (Inoue, Kozawa et al. 2011). Furthermore, otherwise healthy humans exposed to reduced kidney tissue oxygenation, due to living at high altitude, have 1.8-fold increased risk of non-diabetes related end-stage renal disease (Hochman, Watt et al. 2007). It has also been reported that renal hypoxia may be an independent mechanism for the onset of kidney disease (Friederich-Persson, Thorn et al. 2013) and renal hypoxia is present in patients with diabetes (Inoue, Kozawa et al. 2011).

The conference will cover the scientific basis of the effects of hypoxia for cell signaling, mitochondrial and cellular function and its role in the development of both acute kidney injury and chronic kidney disease. We will also thoroughly discuss currently available and novel techniques to study kidney oxygenation in animal models and patients.

SIGNIFICANCE

It is critical that scientist in the field of kidney oxygen metabolism can interact to discuss recent findings and form a broad multidisciplinary group to facilitate collaborations and advance the current understanding. The creation of a focused group of world-leading scientists in the rapidly emerging area of the role of renal hypoxia in kidney disease will certainly be beneficial in order to allow for exchange of new ideas, identification of possible collaborations and future research directions.

PARTICIPANTS

We expect approximately 60 attendees with approximately 25% of participants from Sweden. Invited speakers are especially encourage to bring graduate students, postdoctoral fellows and junior colleagues that will benefit from interaction with prominent scientists in the field. All abstracts will be presented as poster or oral presentations given enough scientific high and conformation to the scientific theme of the conference.

KEYNOTE SPEAKERS

The invited international speakers originate from Japan, USA, Israel, United Kingdom and Australia, and we are applying for funding for these ten top-scientists, five of which are women. In addition, we have invited six national scientists (no funding applied for), bringing the total to 16 invited speakers, of which seven are women (41%). Reports of publications, citations and H-index listed below are from 2017-02-16.

INTERNATIONAL INVITED SPEAKERS

Ass. Prof. Reiko Inagi,

confirmed speaker.

Graduate School of Medicine and Faculty of Medicine, University of Tokyo, Japan. Her research centers on the pathophysiological role of hypoxia and endoplasmic reticulum stress in relation to the development of kidney disease.

Prof. Masaomi Nangaku,

confirmed speaker.

Division of Nephrology and Endocrinology, University of Tokyo School of Medicine, Japan. His research is centered the role of HIF and epigenetic signaling in the pathogenesis of chronic kidney disease, using state of the art molecular techniques to elucidate complex signaling pathways.

Ass. Prof. Prabhleen Singh,

confirmed speaker.

University of California, San Diego, USA. A young independent PI, she studies the role of kidney oxygen consumption and metabolic adaptations at the onset of sepsis-induced acute kidney injury.

Prof. William Welch

confirmed speaker.

Division of Nephrology and Hypertension, Georgetown University, USA. His research centers on the role of kidney oxygen homeostasis and oxidative stress in the development renal injury during hypertension. With groundbreaking work, he has developed techniques to measure oxygen levels in a single nephron.

Prof. Susan Francis,

confirmed speaker.

School of Physics & Astronomy, University of Nottingham, United Kingdom. Her research is world-leading in using magnetic resonance imaging to evaluate renal hemodynamics and oxygenation.

Prof. Roger Evans,

confirmed speaker.

Department of Physiology, Monash University, Australia. His research centers on the role of renal oxygenation in the development of acute kidney injury and he has in particular developed techniques for long-term measurements of renal oxygenation in conscious animals.

Prof. Jennifer Pollock,

confirmed speaker.

Nutrition Obesity Research Center, University of Alabama at Birmingham, USA. Her research centers endothelin-dependent endoplasmic reticulum stress and renal hypoxia in type 1 diabetes.

Dr. Anita T Layton,

confirmed speaker.

Biomedical Engineering, Duke University, USA. She has done pioneering work to establish modeling techniques to better understand the aspects of renal physiology and oxygenation.

Prof. Phillip Darwin Bell,

confirmed speaker.

University of Alabama at Birmingham, USA. His research centers on the role of kidney oxygen homeostasis in polycystic kidney disease.

Prof. Samuel Heyman,

confirmed speaker.

Department of Medicine, Hebrew University of Jerusalem, Israel. He is one of the pioneers in the field of kidney oxygen homeostasis and kidney injury. His research focuses on the role of hypoxia inducible factors in acute kidney injury.

Prof. Sven-Erik Ricksten,

confirmed speaker.
Department of Anesthesiology and Intensive Care, Gothenburg University, Sweden. His research centers on the role of oxygen metabolism contributing to acute kidney injury. With an impressive methodological approach, he measures real-time renal oxygen metabolism in patients at risk of developing acute kidney injury and his group is one of very few laboratories that can perform these measurements in patients.

Prof. Volker Haase,

confirmed speaker.

Department of Medicine Biochemistry and Biophysics, Karolinska Institutet, Sweden. He studies the molecular and cellular basis of hypoxia responses in the adult kidney, during kidney development and in relation to renal anemia.

Ass. Prof. Sergiu-Bogdan Catrina,

confirmed speaker.

Department of Molecular Medicine and Surgery, Karolinska Institutet, Sweden. His research focuses on the role of prolyl hydroxylases and HIF-signaling in diabetic nephropathy. He has 46 publications with 832 citations and an H-index of 14.

Dr. Malou Friederich-Persson,

confirmed speaker.

Department of Medical Cell Biology, Uppsala University, Sweden. As a postdoctoral fellow she focuses on the role of uncoupling proteins and mitochondria efficiency in renal oxygen homeostasis in type 1 diabetes.  She has 19 publications with 300 citations and an H-index of 8.

Ebba Sivertsson,

confirmed speaker.

Department of Medical Cell Biology, Uppsala University, Sweden.
She is an early-stage researcher investigating renal oxygenation in patients with newly diagnosed type 1 diabetes.
 

Prof. Fredrik Palm,

confirmed speaker.

Department of Medical Cell Biology, Uppsala University, Sweden.
He has 103 publications with 2473 citations and an H-index of 28.
 

PROGRAM


August 17-20th 2017

The preliminary program of sessions:

Techniques to measure kidney oxygen homeostasis

Hypoxia inducible factors and kidney oxygen homeostasis in health and disease

ER-stress and renal stress responses in the regulation of kidney oxygen homeostasis

Mitochondrial function and regulation of kidney oxygen homeostasis

The role of kidney oxygen homeostasis in acute kidney injury

The role of kidney oxygen homeostasis in chronic kidney disease

“Poster teasers”

In each session, 2-3 abstracts will be selected to be oral presentations. In the session called “poster teasers”, poster presenters will get one power point slide and one minute to present a short teaser and inspire attendees to come and discuss science at their posters. Each day includes ample time for poster viewing and poster awards and oral presentations are awarded on a peer-review basis.

DISSEMINATION ACTIVITIES


All invited speakers and presenters of abstracts will have to opportunity to submit manuscripts for publication in Acta Physiologica (impact 4.066). We expect that the conference will result in at least 25 submissions for publication. Furthermore, all accepted abstracts will be presented as a joint volume and distributed to the attendees.
 

SCIENTIFIC COMMITTEE

  1. Fredrik Palm, chair

  2. Malou Friederich-Persson, co-chair

  3. Volker Haase, Karolinska Institutet

  4. Sven-Erik Ricksten, Göteborgs Universitet

  5. Reiko Inagi, University of Tokyo
     

REGISTRATION

For registration please contact: Malou Friederich-Persson at malou.friederich@mcb.uu.se regarding how to register and for submitting abstracts.