Group members

The links below lead to University directory

Ingela Parmryd

The functional organisation of the T cell plasma membrane

The plasma membrane of eukaryotic cells contains nanodomains, commonly referred to as lipid rafts, where the lipids are more tightly packed (ordered) than in the rest of the plasma membrane. Domains of different order help segregating molecules and are important for processes like membrane tubulation, signal transduction and infection. In model membranes lateral lipid-lipid interactions are sufficient for the formation of ordered domains. In contrast, we have demonstrated that in cells ordered domains form when actin filaments are pinned to the plasma membrane via phosphoinositides and when outer leaflet receptors are pinned by antibodies, suggesting that the mechanism for order domain formation involves both lipid-protein interactions and interleaflet lipid communication. We are interested in the involvement of ordered plasma membrane domains in signal transduction both in αβ T cells that recognise antigens presented by MHCs and in γ9δ2 T cells that do not. We are also interested in membrane topography. The development of image analysis tools is integrated into our research.

Ongoing Projects...
 


For further information about this research group please contact
Docent Ingela Parmryd

Financial support

2016-2019

3.2 million SEK

Swedish
Research
Council

“The functional interplay between lipid packing and molecular clustering in T cell signalling”
 

2013-2016

3 million SEK

AFA
Insurance

“The expansion of highly potent tumour cell killing γ δ T cells from healthy individuals and cancer patients”



Collaborators

  • Dr Fredrik Bergholm (Royal Institute of Technology, Stockholm)
  • Professor Jonas Bergkvist (Department of Chemistry, Uppsala University)
  • Dr Helgi Birgisson (Department of Surgical Sciences, Uppsala University)
  • Professor Ingrid Faye (Department of Molecular Biosciences, Stockholm University)
  • Professor Yuri Korchev & Dr Andrew Shevshuk (Imperial College, London, UK)
  • Drs Ida-Maria Sintorn & Robin Strand(Centre for Image Analysis, Swedish University of Agricultural Sciences & Uppsala University)