Group members

The links below lead to University directory

Olof Idevall-Hagren

Ongoing projects:

Organelle communication via membrane contacts sites (MCS)

Extended-Synaptotagmins generate ER-PM contacts

Optogenetic tool development and implementation

Plasma membrane PI(4,5)P2 regulate insulin secretion

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Organelle communication via membrane contacts sites (MCS)

The architecture of the prototypic mammalian cell has been the focus of intense study since the early days of microscopy. With the development of electron microscopy for the biological sciences in the 1950’s came the detailed characterization of most cellular organelles, like the endoplasmic reticulum (ER), the Golgi apparatus and secretory vesicles. More recently, using live cell imaging techniques, it has been found that these organelles are highly dynamic structures that constantly reform, reshape and redistribute within the cell. Many organelles also seem to communicate through direct contacts, formed by protein and lipid complexes. Such membrane contact sites (MCS) are hubs for the transfer of lipids, ions and proteins between the organelles and key to the normal function of these cellular compartments. With the insulin secreting pancreatic ß-cell as our model, we employ high-resolution fluorescence microscopy together with genetically encoded biosensors and molecular tools to study and manipulate these cellular structures in order to better understand their function.

Figure 1: Schematic drawing depicting an insulin-secreting pancreatic b-cell. The membrane-enclosed endoplasmic reticulum (ER) of these cells is distributed throughout the cytosol of the cell and makes contacts with numerous other membranes, including the plasma membrane (PM) and the mitochondria (Mito.). Numerous processes occur at these membrane contact sites (MCS) but little is known about their composition.


For further information about this research group please contact
Olof Idevall-Hagren

Financial support

2016-2019


Swedish Research Council

(VR, Unga forskare-MH)

Organelle dynamics in pancreatic beta cell physiology and pathophysiology
 

2014-2017


Göran Gustafssons stiftelse

 

The Importance of Endoplasmic Reticulum – Plasma Membrane Contacts in the Regulation of Beta-cell Function and Insulin Secretion
 

2014-2016


Malin och Lennart Philipsons stiftelse

Activity-dependent modulation of the endoplasmic reticulum


Other funding

  • 2016-2019
    Novo-Nordisk foundation

  • 2016-2018
    Magnus Bergwalls stiftelse

  • 2016-2019
    STINT (Joint China-Sweden mobility grant)

  • 2016-2017
    Åke Wibergs stiftelse

  • 2011-2014
    Swedish research council (postdoctoral fellowship)



Collaborators

within the Department of Medical Cell Biology:

  • Anders Tengholm
  • Sebastian Barg
  • PO Carlsson

outside the Department of Medical Cell Biology:

  • Pietro De Camilli (Yale University, New Haven, CT),
  • Joerg Bewersdorf (Yale University, New Haven, CT).