Group members

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Sebastian Barg

Mechanisms of regulated exocytosis

Exocytosis is fundamental to every cell and crucial to intracellular transport, protein sorting, and cell-to-cell communication. In neurons and endocrine cells, exocytosis leads to the release of neurotransmitters or hormones, and defects in this process can underlie diseases, such as type-2 diabetes. In our lab we are interested in the cell biology of insulin secretion, with a focus on the life-cycle of insulin-containing secretory granules. We study exocytosis in pancreatic ß-cells using advanced light microscopy (TIRF, super-resolution and single molecule imaging) in combination with electrophysiology. Both methods are sensitive enough to observe single granules and even individual protein molecules in a living cell.

Ongoing Projects...


For further information about this research group please contact Sebastian Barg

Financial support

  • Swedish Science Council/Vetenskapsrådet
  • Diabetes Wellness Foundation
  • Hjärnfonden
  • EXODIAB (Excellence of Diabetes Research in Sweden)
  • Swedish Diabetes Society
  • European Foundation for the Study of Diabetes
  • Barndiabetesfonden
  • NovoNordisk foundation
  • Göran Gustafsson foundation
  • Family Ernfors foundation
  • Zetterlings foundation
  • OE&E Johanssons foundation

      

        

Collaborators

within the Department of Medical Cell Biology:

  • Anders Tengholm
  • Olof Idevall

outside the Department of Medical Cell Biology:

  • Bryndis Birnir (Uppsala University)
  • Morten G Pedersen (Padova IT)
  • Giuliana Cortese (Padova IT)
  • Jakob Sörensen (Copenhagen University)