Group members

The links below lead to the university directory.

Sebastian Barg

Mechanisms of regulated exocytosis

Exocytosis is fundamental to every cell and crucial to intracellular transport, protein sorting, and cell-to-cell communication. In neurons and endocrine cells, exocytosis leads to the release of neurotransmitters or hormones, and defects in this process can underlie diseases, such as type-2 diabetes. In our lab we are interested in the cell biology of insulin secretion, with a focus on the life-cycle of insulin-containing secretory granules. We study exocytosis in pancreatic ß-cells using advanced light microscopy (TIRF, super-resolution and single molecule imaging) in combination with electrophysiology. Both methods are sensitive enough to observe single granules and even individual protein molecules in a living cell.

Ongoing Projects...


For further information about this research group please contact Sebastian Barg

Financial support

  • Swedish Science Council/Vetenskapsrådet
  • Diabetes Wellness Foundation
  • Hjärnfonden
  • EXODIAB (Excellence of Diabetes Research in Sweden)
  • Swedish Diabetes Society
  • European Foundation for the Study of Diabetes
  • Barndiabetesfonden
  • NovoNordisk foundation
  • Göran Gustafsson foundation
  • Family Ernfors foundation
  • Zetterlings foundation
  • OE&E Johanssons foundation

      

        

Collaborators

within the Department of Medical Cell Biology:

  • Anders Tengholm
  • Olof Idevall

outside the Department of Medical Cell Biology:

  • Bryndis Birnir (Uppsala University)
  • Morten G Pedersen (Padova IT)
  • Giuliana Cortese (Padova IT)
  • Jakob Sörensen (Copenhagen University)