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Quantitative Imaging of Molecular Mechanisms Underlying Islet Hormone Secretion


Prof. David W. Piston

Department of Cell Biology and Physiology,
Washington University School of Medicine,
St. Louis, MO, USA

Wednesday, September 12,
15:15   BMC B21

The research focus of David Piston’s lab is the understanding of glucose-regulated hormone secretion from pancreatic islets using state-of-the-art fluorescence imaging methods, quantitative microscopy, biochemical and molecular biological techniques as well as mathematical models. Over the last 20 years, the lab has developed instrumentation and probe technology for quantitative measurements broadly applicable to cell biology, physiology, and whole-organism imaging experiments. Many properties of intact islets match those seen in vivo, and the Piston lab is focusing on methods that allow them to assay living islet functions quantitatively. Such studies are proving critical to advancing our understanding of the regulation of insulin secretion from b‑cells and glucagon secretion from α-cells.

Host:  Anders Tengholm