Leif Jansson

Pancreatic islet circulation in diabetes

Disturbances in carbohydrate and lipid metabolism seen during impaired glucose tolerance and type 2 diabetes are associated with an endothelial dysfunction favouring vascular disease. The role of the regulation of the blood circulation for the normal function of the islets of Langerhans and white adipose tissue, especially under pathological conditions, is still incompletely understood.
We have previously demonstrated aberrations in especially islet blood perfusion during impaired glucose tolerance or type 2 diabetes. These blood flow changes may by themselves affect islet and adipocyte function by impairment of endothelial function. Furthermore, most of the treatment regimes for type 2 diabetes decrease the increased islet blood flow suggesting a role for the blood perfusion in the pathogenesis of the disease. However, to what extent this affects also white adipose tissue blood flow is still unclear.
By a combination of studies in vivo, on isolated single islets with attached artrioles and in vitro studies we intend to study disturbances in blood flow regulation of islet and white adipose tissue and how to amend these.
A careful analysis of the factors responsible for the regulation of islet and adipose tissue blood perfusion in type 2 diabetes will provide knowledge on the role of these factors in the pathogenesis of islet functional deterioration, and hopefully open up new possibilities for treatment of this serious and disabling disease.

For further information about this research group please contact
Professor Leif Jansson: Leif.Jansson@mcb.uu.se