Nils Welsh

Both in Type 1 and Type 2 diabetes there is a deficit in the number and function of β-cells. The reasons for increased death and decreased regeneration and function of β-cells remain unknown. Therefore, our overall aim is to study signaling events that participate in β-cell death, function and regeneration. We currently focus on signaling via the non-receptor tyrosine kinase c-Abl, ROS production occurring via the NADPH-dependent oxidases (NOX) and the transcription factor ZBED6, which appears to control β-cell proliferation and function. For these purposes we are studying human β-cells (EndoC-betaH1 cells and human islets) and we utilize techniques such as RNA-seq, CHiP-seq, qPCR, immunoblot analysis, flow cytometry, viral vector-mediated transduction, siRNA and in vivo models.

Ongoing Projects...

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Professor Nils Welsh