Olof Idevall-Hagren

Ongoing projects:

Organelle communication via membrane contacts sites (MCS)

Extended-Synaptotagmins generate ER-PM contacts

Optogenetic tool development and implementation

Plasma membrane PI(4,5)P2 regulate insulin secretion

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Extended-Synaptotagmins generate ER-PM contacts

We have characterized a family of proteins called the Extended-Synaptotagmins (E-Syts). These ER-anchored proteins bind to the plasma membrane upon changes in the cytosolic Ca2+ concentration (see Figure 2), thus generating physical connections between the two membranes. We are currently trying to understand the biological function of these proteins.

Figure 2: A. Electron micrograph of a fibroblast where the ER is stained black. Notice how parts of the ER are in close proximity of the cell periphery (red box). B. Schematic illustration depicting Extended-Synaptotagmin-1 (E-Syt1), an ER-anchored protein that also binds the plasma membrane by interactions with specific lipids. C. Confocal microscopy images of a very flat cell expressing fluorescence-tagged E-Syt1 under conditions where the cytoplasmic Ca2+ concentration is low or high. Notice how E-Syt1 aggregate at the plasma membrane when the Ca2+ concentration increases.


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Olof Idevall-Hagren